Research infrastructures, as providers of advanced services and as procurers of leading-edge technologies, have an innovation potential that has not always been sufficiently exploited. Opportunities provided by the development of components, instruments, services and knowledge for the implementation and upgrade of research infrastructures, could be better exploited to push the limits of existing technologies. There is a clear innovation potential associated with procurement from industry during the construction and upgrade of research infrastructures. A co-innovation approach to continuously generate, scale and deploy breakthrough technologies with market and social value needs to be adopted by research infrastructures. INFRAINNOV call is designed to meet these aims.